Research Journal of Pharmacology and Pharmacodynamics

Abstract

In the present study, aqueous extract of leaves of Capparis zeylanica Linn, Annona reticulata Linn and Clerodendron phlomidis Linn were given at a dose of 200mg/kg, 400mg/kg (p.o.).

The antipyretic activity was done after inducing hyperpyrexia by injecting subcutaneously 20% aqueous suspension of Brewer's yeast in rats. Rats developing 0.5° C-1° C or more rises in rectal temperature 18 h after injection were taken for study.

The results proved that the aqueous extract of leaves of Clerodendron phlomidis Linn and Annona reticulata Linn has significant antipyretic activity and were compared with paracetamol (150 mg/kg body weight, p.o.), a standard antipyretic agent. Aqueous extract of leaves of Capparis zeylanica Linn has not reduced elevated fever in experimental rats.

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